Table 2. Alterations in neuropeptide expression in Y1-/- mice.
| Brain area | Neuropeptide | Control, % | Y1-/-, % |
|---|---|---|---|
| Accessory olfactory bulb | NPY | 100 ± 6.3 (5) | 77 ± 4.7 (4)* |
| Medial amygdala | CART | 100 ± 3.9 (5) | 74 ± 7.0 (5) * |
| Central amygdala | CART | 100 ± 2.3 (5) | 103 ± 3.2 (5) |
| Arcuate nucleus | NPY | 100 ± 4.2 (10) | 86 ± 10.2 (4) |
| AgRP | 100 ± 3.3 (9) | 91 ± 2.8 (4) | |
| CART | 100 ± 2.7 (10) | 76 ± 4.7 (5) *** | |
| POMC | 100 ± 2.7 (10) | 79 ± 1.8 (5) *** | |
| Paraventricular nucleus | TRH | 100 ± 2.6 (6) | 111 ± 3.5 (5) * |
| CRH | 100 ± 2.1 (5) | 91 ± 9.4 (5) | |
| Scattered forebrain neurons | GnRH | 100 ± 2.0 (5) | 126 ± 3.0 (4) ** |
Data represent mean labeling intensity of neurons of the specified areas, given as percent of control ± SEM. The number of mice is shown in parentheses. AgRP, agouti-related protein; CRH, corticotropin-releasing hormone; TRH, thyroid-stimulating hormone-releasing hormone. Significant post hoc effects vs. controls are indicated by asterisks (*, P < 0.05; **, P < 0.01; ***, P < 0.0001).