TABLE 1.
Synonymous mutations in the yopN1-12 secretion signal and their effect on the secretion of YopN1-12-Npt
| Codon | Amino acid | Wild-type codon | Wobble codon | % Secretion |
|---|---|---|---|---|
| ACC | 24 | |||
| 2 | Thr (T) | ACG | ACA | 30 |
| ACU | 26 | |||
| ACC | 18 | |||
| 3 | Thr (T) | ACG | ACA | 25 |
| ACU | 26 | |||
| CUA | 25 | |||
| UUA | 37 | |||
| 4 | Leu (L) | CUU | UUG | 35 |
| CUC | 21 | |||
| CUG | 30 | |||
| 5 | His (H) | CAU | CAC | 24 |
| 6 | Asn (N) | AAC | AAU | 17 |
| CUU | 1 | |||
| UUA | 35 | |||
| 7 | Leu (L) | CUA | UUG | 27 |
| CUC | 1 | |||
| CUG | 23 | |||
| UCA | 20 | |||
| UCC | 25 | |||
| 8 | Ser (S) | UCU | UCG | 24 |
| AGU | 13 | |||
| AGC | 16 | |||
| 9 | Tyr (Y) | UAU | UAC | 10 |
| GGG | 5 | |||
| 10 | Gly (G) | GGC | GGU | 24 |
| GGA | 16 | |||
| 11 | Asn (N) | AAU | AAC | 12 |
| ACG | 16 | |||
| 12 | Thr (T) | ACC | ACA | 24 |
| ACU | 22 |