Table 2.
Sensitivity and specificity of breast cancer screening mammography by menopausal status and age among women who have never used hormone replacement therapy (HRT)
|
Characteristic and outcome at mammography
|
Breast cancer*
|
Sensitivity
|
Specificity
|
|||||
|---|---|---|---|---|---|---|---|---|
| Yes | No | Crude | Adjusted†(95% CI) | P value‡ | Crude | Adjusted†(95% CI) | P value‡ | |
| Menopausal status | ||||||||
| Premenopausal:
|
|
|
|
|
|
|
||
| Screen positive
|
39
|
356
|
90.7
|
81.0 (51.5 to 94.5)
|
94.6
|
96.9 (96.4 to 97.2)
|
||
| Screen negative
|
4
|
6 228
|
||||||
| Perimenopausal: | 0.6 | <0.0001 | ||||||
| Screen positive
|
50
|
311
|
94.3
|
89.5 (66.6 to 97.3)
|
95.4
|
97.2 (96.8 to 97.6)
|
||
| Screen negative
|
3
|
6 521
|
||||||
| Postmenopausal:
|
|
|
|
|
|
|
||
| Screen positive
|
207
|
931
|
91.2
|
90.9 (83.7 to 95.1)
|
97.9
|
98.0 (97.8 to 98.1)
|
||
| Screen negative
|
20
|
44 050
|
|
|
||||
| Age (years) | ||||||||
| 50-54§:
|
|
|
|
|
|
|
||
| Screen positive
|
42
|
321
|
95.5
|
89.9 (64.3 to 97.8)
|
97.0
|
98.1 (97.7 to 98.3)
|
||
| Screen negative
|
2
|
10 518
|
||||||
| 55-59§: | 0.6 | 0.4 | ||||||
| Screen positive
|
59
|
263
|
86.8
|
85.8 (72.9 to 93.1)
|
98.2
|
98.1 (97.9 to 98.4)
|
||
| Screen negative
|
9
|
14 003
|
||||||
| 60-64§:
|
|
|
|
|
|
|
||
| Screen positive
|
106
|
327
|
92.2
|
91.3 (82.6 to 95.8)
|
98.3
|
98.3 (98.1 to 98.5)
|
||
| Screen negative | 9 | 18 804 | ||||||
*
Diagnosed at screening or in the 12 months after screening.
†
Adjusted for age, screening centre, likelihood of previous NHS breast screening programme screening, body mass index, and previous breast surgery, when appropriate
‡
For heterogeneity.
§
Postmenopausal women only