Table 1.

Antimetabolite therapy [4^▪]

	Level of evidence in sarcoidosis	Most common toxic effects (>1%)	Rare but important toxic effects
Methotrexate	Double-blind placebo- controlled trials, prospective case series and case reports	Nausea, mouth ulcers, leucopenia, hepatotoxicity, nausea, and infections	Pneumonitis and teratogenic
Azathioprine	Prospective case series and case reports	Leucopenia, nausea, and infections	Severe leucopenia, hepatotoxic effects, pancreatitis, and skin cancer
Leflunomide	Double-blind placebo- controlled trials, prospective case series, and case reports	Leucopenia, hepatotoxic effects, infections, and alopecia	Pneumonitis, teratogenic, peripheral neuropathy, and hypertension
Mycophenolate mofetil	Case series	Nausea, diarrhea, and infections	Skin cancer