FIG. 1.

Domain organization of known type I FASs and related multienzymes. Arrows indicate open reading frames. Their subdivision into functional domains is not shown to scale. With the exception of FAS1 and FAS2, the indicated gene pairs are chromosomally linked in tandem orientation. The indicated PKS combinations encode putative heteromeric multienzymes comprising a complete set of FAS domains. Brackets indicate intramolecular FAS modules. L, acyl-CoA ligase. Adapted from references 25 and 93.