Table 3. Comparison of human cell lines with other expression systems in the production of therapeutic proteins.

Advantages	Disadvantages
• Absence of potentially immunogenic PTMs due to  human-compatible glycosylation • Easily grown in suspension serum-free culture • Achieve rapid reproduction • Amenable to a number of transfection methods	• Clinical experience is not as extensive as for other cell lines,  although experience is growing • Potential susceptibility to human viral contamination