TABLE 2.
Examples of bacterial toxins produced as preformed “A-B” structures found in solution
| Bacterium | Toxin (reference) | Structure (mol mass [kDa]/A:B ratio) |
|---|---|---|
| Clostridium botulinum | Botulinum neurotoxins A-G (332a) | Single protein (150/1:1) |
| Clostridium difficile | Toxins A and B (434a) | Single protein (∼270-308/1:X)a |
| Clostridium novyi | Alpha toxin (182a) | Single protein (250/1:X)a |
| Clostridium sordellii | Hemorrhagic and lethal toxins (252a) | Single protein (∼260-300/1:X)a |
| Clostridium tetani | Tetanus neurotoxin (332a) | Single protein (150/1:1) |
| Corynebacterium diphtheriae | Diphtheria toxin (330a) | Single protein (58/1:1) |
| Pseudomonas aeruginosa | Exotoxin A (330a) | Single protein (67/1:1) |
| Bordetella pertussis | Pertussis toxin (246a) | Multiple proteins (105/1:4) |
| Escherichia coli | Heat-labile enterotoxin (181) | Multiple proteins (85/1:5) |
| Shigella dysenteriae and other Enterobacteriaceae | Shiga and Shiga-like toxins (2) | Multiple proteins (∼70/1:5) |
| Vibrio cholerae | Cholera toxin (181) | Multiple proteins (85/1:5) |
a
Repetitive “B” oligopeptide domains of different lengths are evident within the C terminus of the large clostridial toxins produced by C. difficile, C. novyi, and C. sordellii.