Table 4.

Relationship between constituents in tobacco filler and smoke

		tobacco filler						cigarette smoke
		nicotine	nitrite	nitrate	NNN	NNK	Total TSNAa	nicotine	phenanthrene	pyrene	BaP	NNN	NNK
tobacco filler	Nitrite	r = 0.162 P = 0.23
	Nitrate	−0.441 0.0007	0.356 0.007
	NNN	−0.289 0.03	0.038 0.78	0.471 0.0002
	NNK	−0.099 0.47	0.176 0.19	0.257 0.06	0.449 0.0005
	Total TSNAa	−0.280 0.037	0.095 0.49	0.488 0.0001	0.944 <0.0001	0.711 <0.0001
cigarette smoke	Nicotine	0.240 0.075	−0.124 0.36	−0.210 0.12	−0.413 0.0016	−0.227 0.093	−0.413 0.0016
	Phenanthrene	0.353 0.0076	0.037 0.79	−0.184 0.17	−0.276 0.039	−0.148 0.28	−0.285 0.033	0.731 <0.0001
	Pyrene	0.338 0.011	0.092 0.50	−0.136 0.32	−0.265 0.048	−0.106 0.44	−0.263 0.050	0.725 <0.0001	0.972 <0.0001
	BaP	0.317 0.017	0.029 0.83	−0.144 0.29	−0.267 0.047	−0.138 0.31	−0.272 0.043	0.749 <0.0001	0.958 <0.0001	0.965 <0.0001
	NNN	−0.291 0.029	0.065 0.63	0.523 <0.0001	0.746 <0.0001	0.581 <0.0001	0.806 <0.0001	−0.259 0.054	−0.123 0.37	−0.099 0.47	−0.103 0.45
	NNK	−0.109 0.42	0.097 0.48	0.347 0.009	0.490 0.0001	0.829 <0.0001	0.695 <0.0001	−0.049 0.72	0.029 0.83	0.055 0.69	0.048 0.73	0.807 <0.0001
	Total TSNAa	−0.233 0.084	0.123 0.37	0.513 <0.0001	0.586 <0.0001	0.633 <0.0001	0.707 <0.0001	−0.041 0.76	0.067 0.62	0.098 0.47	0.104 0.44	0.922 <0.0001	0.912 <0.0001

^aTotal TSNA, sum of the four TSNA analyzed in this study: NNN, NNK, NAT, and NAB.