FIG. 2.

Confirmation of the E7 7-15 specificity of the screen-positive T-cell clones and identification of their restriction element. (a) The E7 7-15-specific T-cell clones recognize the E7 7-15 peptide but not E7-vac-infected autologous EBV-LCL. A total of 10³ T-cell clones were plated along with 10⁵ autologous EBV-LCL. (b) The results suggest that the restriction element for the E7 7-15 peptide is likely to be the HLA-B48 molecule. A total of 10³ T-cell clones were plated along with 10⁵ EBV-LCL matching at the designated HLA types. Only the HLA class I molecules matching the subject being studied are indicated.