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. Author manuscript; available in PMC: 2017 Sep 1.
Published in final edited form as: Adv Mater. 2016 Jul 6;28(36):7984–7992. doi: 10.1002/adma.201601646

Scheme 1.

Scheme 1

PSi-polymer nanocomposite fabrication. 1. Electrostatic assembly of PEGDB on the negatively charged PSNP surface. 2. Purification of nanocomposites by removal of free PEGDB in the supernatant following centrifugation. 3. Buffering the nanoparticle solution to physiologic pH increases polymer self-aggregation, potentially contributing to hydrophobic stabilization of the surface coating and drug loading into the PSNP interior pores. The bottom panel shows surface charge of oxidized PSNPs, PEGDB, and nanocomposites during assembly at pH 5.5, and after buffering pH to 7.4.