Table 2.
Patients with atrial fibrillation in primary care: all women and men, and women and men without persistent warfarin treatment (“per protocol” warfarin treatment), respectively, divided into patients without or with first hospital-admitted ischemic stroke (IS), during 2001–2010 by scores on CHA2DS2-VASc, with number of patients (percentage). Incidence rates (IR) for IS in patients without PP-warfarin treatment. Numbers needed to treat (NNT) shown for prevention of first ischemic stroke by warfarin treatment during 5.4 years of follow-up
| CHA2DS2- VASc: | Women | Men | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| All | Without PP-warfarin | All | Without PP-warfarin | |||||||||
| No IS | IS | No IS | IS | No IS | IS | No IS | IS | |||||
| n | n (%) | n | n (%) | IR | NNT | n | n (%) | n | n (%) | IR | NNT | |
| 0 | – | – | – | – | – | 720 | 39 (5.1) | 482 | 34 (6.6) | 1.09 (0.78–1.52) | 22.1 | |
| 1 | 258 | 21 (7.5) | 184 | 19 (9.4) | 1.55 (0.99–2.42) | 14.9 | 1064 | 81 (7.1) | 581 | 71 (10.9) | 1.86 (1.48–2.36) | 11.3 |
| 2 | 494 | 73 (12.9) | 309 | 67 (18.3) | 3.20 (2.51–4.06) | 6.6 | 1557 | 159 (9.3) | 888 | 133 (13.0) | 2.52 (2.12–2.98) | 10.8 |
| 3 | 1157 | 191 (14.2) | 730 | 165 (18.4) | 3.71 (3.18–4.32) | 7.9 | 1287 | 194 (13.1) | 696 | 161 (18.8) | 3.81 (3.27–4.45) | 7.4 |
| 4 | 1419 | 231 (14.0) | 895 | 206 (18.7) | 3.84 (3.35–4.40) | 7.1 | 631 | 133 (17.4) | 354 | 109 (23.5) | 5.27 (4.37–6.36) | 6.4 |
| 5 | 814 | 167 (17.0) | 498 | 143 (22.3) | 4.95 (4.20–5.84) | 6.8 | 225 | 58 (20.5) | 131 | 47 (26.4) | 5.96 (4.48–7.94) | 6.3 |
| 6 | 266 | 60 (18.4) | 156 | 52 (25.0) | 5.91 (4.51–7.76) | 5.5 | 70 | 28 (28.6) | 36 | 25 (41.0) | 10.70 (7.23–15.84) | 3.0 |
| 7 | 57 | 22 (27.9) | 36 | 16 (30.8) | 6.28 (3.85–10.26) | 11.7 | 17 | 4 (19.1) | 9 | 3 (25.0) | 5.66 (1.83–17.65) | N/A |
| 8 | 14 | 3 (17.7) | 10 | 2 (16.7) | 4.12 (1.03–16.48) | N/A | 1 | 1 (50.0) | 0 | 1 (100.0) | N/A | N/A |
| 9 | 1 | 0 (0.0) | 1 | 0 (0.0) | N/A | N/A | – | – | – | – | – | |
| All | 4480 | 768 (14.6) | 2810 | 670 (19.3) | 3.89 (3.61–4.20) | 7.3 | 5,572 | 697 (11.1) | 3177 | 584 (15.5) | 2.98 (2.75–3.23) | 9.1 |
Values for all patients and for those with no warfarin treatment according to “per protocol”-analysis. Incidence Rate per 100 Person-Years at Risk (95% CI) shown for ischemic stroke without warfarin treatment.
NNT denotes “numbers needed to treat” during a mean follow-up of 5.4 years