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. 2016 Dec 30;58(12):1159–1166. doi: 10.1097/JOM.0000000000000879

FIGURE 2.

FIGURE 2

Mechanism of nucleic acid delivery by LVVs. Viral particles containing lentiviral RNA fuse to the target cell, releasing the LVV RNA into the cell. Reverse transcription converts the LVV RNA to DNA, which integrates into the host genome and is expressed by the infected cell. After integration, the cell can become cancerous through LVV transgene expression or insertional mutagenesis. Reverse transcription can be blocked by NRTIs [nucleos(t)ide reverse transcriptase inhibitors] and LVV DNA integration can be blocked with HIV integrase inhibitors. Illustration by Nicole Wolf, MS, ©2016. Printed with permission.