FIG. 3.

Change in antibody titers during treatment of tuberculosis. These graphs include data from only those patients with smear-positive pulmonary tuberculosis who had a positive antibody titer at some point during their treatment but exclude those with isoniazid-resistant tuberculosis (see Fig. 4). Antibody levels obtained during treatment were each compared to the patient's pretreatment level to give a relative antibody titer. The relative antibody titers were then combined to give a mean ± standard error. A logarithmic scale has been used to treat rises and falls in antibody titer equally. Antibody levels were measured by competition with monoclonal antibodies TB23 (which binds to a secreted 19-kDa antigen), TB78 (which binds to the stress protein hsp65), TB71 and TB72 (which bind to a secreted 38-kDa antigen), TB68 (which binds to a 16-kDa α-crystallin stress protein homolog), and ML34 (which binds to lipoarabinomannan).