FIG. 1.

The comparison of hepatic histopathology ranking and A. phagocytophilum-infected neutrophil tissue load (in spleen) between SCID mice treated with anti-CXCR2 or control antibody at the time of infection or 14 days postinfection (initial experiments only). Higher ranks correspond to higher degrees of severity. Differences in histopathologic rank did not differ significantly between anti-CXCR2-treated and NGS control antibody-treated animals in prevention and treatment groups. P values for differences between splenic organism load in prevention and treatment groups are shown. Error bars indicate standard deviations. P values (paired Wilcoxon test for nonparametric data) between columns compare infected cell load (black type) and histopathology ranks (gray type). Experiments were done in duplicate. Shown are the results of the initial experiment; confirmatory experiment data were similar.