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. 2017 Jan;98:212–218. doi: 10.1016/j.envint.2016.11.010

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© 2016 The Authors. Published by Elsevier Ltd.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Fig. 4. — Manhattan plot for a whole-genome methylation analysis of plasma p,p′-DDE levels in relation to ~ 450 k methylation sites (upper panel) with − 10log p-value at the y-axis and the gross position in the genome at the x-axis. The lower panel shows a regional plot for linear regression analysis regarding associations between p,p′-DDE levels and methylation loci in or close to the CYP2B6 gene. The -10log p-values for the associations are given at the y-axis and the positions at chromosome 19 are given at the x-axis. The lead methylation site in this analysis showed a p-value of 6.2 ∗ 10^− 9.