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. 2016 Dec 12;11(12):e0168144. doi: 10.1371/journal.pone.0168144

Fig 5. Impact of development and neutering on histidine-associated metabolites.

Fig 5

Changes in the average abundance of histidine and histidine-derived muscle-associated amino acid derivatives. Both histidine and carnosine decrease significantly in CN compared to EN cats during sexual development and increase to levels similar to EN cats within 2 weeks of neutering (CN (red) and EN (black)). Anserine, the final product detected in this pathway increases significantly in CN cats during sexual development and remains at a stable level, whilst EN cats show a steady increase throughout development. Scaled intensity is relative to the normalised pool of all samples (error bars represent 95% CI).