Table 2. Rate of heart failure and acute myocardial infarction according to baseline fitness levels and results of Multivariable-adjusted Cox Proportional Hazards Models Examining the Association between Fitness and Heart Failure and Acute Myocardial Infarction among Participants in the Cooper Center Longitudinal Study.
| Men | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Heart Failure | Acute MI | Total Mortality | |||||||||||
| Person- years | Events | Rate | Hazard ratio# (95% CI) | χ2 | P-value | Events | Rate | Hazard ratio (95% CI) | χ2 | P-value | Events | Rate | |
| Q1 (low Fit) | 19,378 | 331 | 17.1 | 1.0 | ----- | ---- | 204 | 10.5 | 1.0 | ----- | ---- | 677 | 34.9 |
| Q2-3 (Mod Fit) | 45,131 | 387 | 8.6 | 0.60 (0.49-0.75) | 20.7 | < 0.001 | 319 | 7.1 | 0.74 (0.59-0.92) | 7.6 | .006 | 1037 | 23.0 |
| Q4-5 (High Fit) | 41,346 | 189 | 4.6 | 0.31 (0.24-0.41) | 71.6 | < 0.001 | 206 | 5.0 | 0.56 (0.43-0.71) | 21.6 | < 0.001 | 674 | 16.3 |
| Fitness (per MET) | 0.79 (0.75-0.83) | 81.7 | < 0.001 | 0.91 (0.87-0.95) | 18.6 | < 0.001 | |||||||
| Women | |||||||||||||
| Q1 (low Fit) | 4,024 | 35 | 8.7 | 1.0 | ---- | ----- | 23 | 5.7 | 1.0 | ---- | ---- | 99 | 24.6 |
| Q2-3 (Mod Fit) | 10,862 | 72 | 6.6 | 0.53 (0.31-0.93) | 5.0 | .03 | 41 | 3.8 | 0.73 (0.40-1.32) | 1.1 | 0.29 | 177 | 16.3 |
| Q4-5 (High Fit) | 12,772 | 37 | 2.9 | 0.38 (0.20-0.71) | 9.1 | 0.003 | 39 | 3.1 | 0.62 (0.33-1.17) | 2.16 | 0.14 | 126 | 9.9 |
| Fitness (per MET) | 0.81 (0.68-0.96) | 6.1 | 0.01 | 0.97 (0.83-1.13) | 0.2 | 0.68 | |||||||
*
Rate per 1000 person-years;
#
Reference group for Hazard ratio calculation is High fit (Q4-5); METS: metabolic equivalents