Table 3. Summary of Randomized Trials of Propafenone in New Onset Atrial Fibrillation.

Study	No. of patients	AF onset	outcome	Comparison	results
Capucci A et al 1994 [56]	87	<8 days	Conversion to SR	Oral Propafenone vs IV digoxine=quinidine vs placebo	(62% vs. 17%, 83% vs. 34%; 86% vs. 55%; P < 0.01. 6 h (62% vs. 38%; P < 0.05) dig. 12 h (83% vs. 48%; P < 0.05 dig+quin
Bellandi F et al, 1995 [57]	182		Conversion to SR	IV Propafenone vs IV placebo	90.9% vs 32.1% , P<0.0005.
Boriani G et al 1995 [58]	87	<7 days	Conversion to SR	I.V. propafenone vs oral propafenone vs placebo	66% vs 69% vs 24% (8 h); p < 0.005
Botto GL et al, 1996 [59]	283	<72 hours	Conversion to SR	Oral propafenone vs digoxine and placebo.	57% vs 25%, P<0.001
Fesco et al 1996 [60]	75	<72 Hr	Conversion to SR	IV propafenone vs placebo	58.5% vs 29.4% (within 3 h or until conversion occurred); p < 0.01
Azpitarte et al 1997[61]	55	<7 days	Conversion to SR	Oral propafenone vs placebo	41% vs 8% (2h) p=0.005. 65% vs 31% (6h) P=0.015
Boriani G et al, 1997[62]	240		Conversion to SR	Oral propafenone vs placebo	45% vs 18%, P<0.001 (3he).
Bianconi L et al, 1998[63]	123	<72 hours	Conversion to SR	I.V. propafenone vs I.V. digoxine vs placebo.	50% vs 25%, P<0.01
Botto et al/1998 [64]	123	<72 h	Conversion to SR	IV propafenone vs oral propafenone vs placebo	53% vs 78% vs 48% (8 h); p < 0.03
Ganau et al/1998 [65]	156	<72 h	Conversion to SR	IV propafenone vs placebo	70.3% vs 17.3% (2 h); p < 0.001
Kochiadakis et al/1998 [66]	143	<48 h	Conversion to SR	IV propafenone vs IV amiodarone vs placebo (digoxin added to all digoxin-naive patients)	78.2% vs 83.3% vs 55.1% (within 1 h); p < 0.02 (drug vs placebo)
Blanc JJ et al/1999 [67]	86	<2 weeks	Conversion to SR	Oral propafenone vs oral amiodarone	56% vs 47% (24 h); p = non significant
Romano S et al/2001[55]	352	N/A	Conversion to SR	Propafenone vs flecainide vs placebo	92.1% vs 89.8% vs 46.3% (24 h); p < 0.05 (drug vs placebo)