Table 2. Summary of Trials Using Continuous Arrhythmia Monitoring to Correlate AT/AF and Stroke Risk.

AT/AF = Atrial tachyarrhythmia/atrial fibrillation, C.I. = Confidence interval, CRT = Cardiac resynchronization therapy, ICD = Implantable cardioverter defibrillator, TIA = Transient ischemic attack

Study Name	Monitoring Device	Prior AT/AF?	AT/AF Burden Threshold	Endpoint Event	Hazard Ratio (C.I.)
MOST Sub-study22	100% Pacemaker	Allowed, but not required	>5 minutes	Death or non-fatal stroke	2.79 [1.51,5.15]
Italian AT500 Registry23	100% Pacemaker	History of symptomatic AT	>24 hours	Ischemic stroke, TIA, or peripheral arterial embolism	3.1 [1.1, 10.5]
TRENDS24	TRENDS24 50% Pacemaker 31% ICD 19% CRT	Allowed, but not required	≥5.5 hours	Ischemic stroke, TIA, or systemic embolism	2.20 [0.96, 5.05]
Biotronik25	100% CRT	Allowed, but not required	≥3.8 hours	Ischemic stroke, TIA, or peripheral arterial embolism	9.4 [1.8, 47.0]
ASSERT27	95% Pacemaker 5% ICD	Excluded	≥6 minutes	Ischemic stroke or systemic embolism	2.49 [1.28, 4.85]