|
Study (First author[ref])
|
Study population (Age population) |
Country |
Follow-up |
Estimation of n-3 PUFAs dietary intake |
Main results(Risk of AF a in the highest intake vs. the lowest intake group) |
|
Cardiovascular Health Study(Mozaffarian [36])
|
4,815 subjects(= 65 years) |
USA |
12 years |
Food Frequency Questionnaire |
Lower AF risk with broiled fish RR 0.70 (95% CI; 0.53-0.91) p=0.008 |
|
Danish Study (Frost [38])
|
47,949 subjects (mean age 56 years) |
Denmark |
5.7 years |
Food Frequency Questionnaire |
Increased AF risk RR 1.34 (95% CI; 1.02-1.76) p = 0.001 |
|
Rotterdam study (Brouwer[ 42])
|
5,184 subjects |
Netherlands |
6.4 years |
Semi-quantitative Food Frequency Questionnaire |
No association RR 1.18 (95% CI; 0.88-1.57) |
|
Physician's Health Study (Aizer[ 40])
|
17,679 male subjects |
USA |
15 years |
Food Frequency Questionnaire |
No association RR 1.46 (95% CI; 0.94-2.28) |
|
Women's Health Initiative (Berry JD [39])
|
46,704 female subjects (50 to 79 years) |
USA |
3 years |
Food frequency questionnaire |
No association RR 1.01 (95% CI; 0.66-1.56) |
|
Framingham Heart Study (Shen J [43])
|
9,640 subjects (4231 male; mean age 62 years) |
USA |
Six years |
Semi-quantitative Food Frequency Questionnaire |
No association RR 1.18 (95% CI: 0.85, 1.64) p = 0.57 |
|
Kuopio study (Virtanen JK [46])
|
2,174 male subjects (42 to 60 years) |
Finland |
17.7 years |
Serum long-chain n-3 PUFAs |
No association with EPA level RR 0.96 (95% CI; 0.64-1.42) p =0.70 Lower AF risk with DHA level RR 0.62 (95% CI; 0.42-0.92) p= 0.02 |
|
Cardiovascular Health study (Wu [47])
|
3,326 subjects (60% women) Mean age: 74.1 ± 5.2 years |
USA |
10 years |
Serum long-chain n-3 PUFAs |
Lower AF risk with total n-3 PUFAs level RR 0.64 (95% CI; 0.52-0.79) p < 0.001 Lower AF risk with DHA level RR 0.77 (95% CI; 0.62-0.96) p = 0.01 |
| AF: atrial fibrillation; RR: relative risk; CI: confidential interval; EPA: eicosapentaenoic acid; DHA: docosahexaenoic acid
|
