Figure 1. Altered E-C coupling in human AF. A) APs recorded at different pacing rates in a control human atrial myocyte (left) and in a cell from a cAF patient (right) (11). B) Intracellular Ca2+ transients measured in human atrial cells from sinus rhythm (left) and cAF (right) patients at physiological temperature. C) Twitch force measurements (22) in myocytes from sinus rhythm and cAF patients are shown at various doses of AVE0118 (IKur blocker).
