Figure 9.

Schematic diagram of CD147 maturation and regulation by caveolin-1. After CD147 enters the Golgi complex, it can mature via two possible pathways. First, it associates with caveolin-1, fails to acquire polylactosamines, and is escorted to the cell surface while still at least partly associated with caveolin-1, in the context of a larger, caveolin-containing complex (Tang and Hemler, 2004). This LG-CD147 does not self-aggregate and does not induce MMP production. Second, with initiation by the action of GnT-V, CD147 acquires β1,6-branched polylactosamines on its N-glycans as it matures to HG-CD147. This molecule has a tendency to self-aggregate and is active in the stimulation of MMP production by neighboring cells. ER, endoplasmic reticulum; Gly, glycosylation.