Table 1.
Research results of biomarkers with at least 4 references
| Test | Studies | Cut-off | n | TP | FP | FN | TN | AUC (95% CI) | Sensitivity (95% CI) | Specificity (95% CI) |
|---|---|---|---|---|---|---|---|---|---|---|
| PCT | 59 | 0.96 (0.5, 1.7) ng/mla | 7376 | 3173 | 847 | 1060 | 2296 | 0.85 [0.82, 0.88] | 0.79 [0.75, 0.83] | 0.78 [0.74, 0.81] |
| CRP | 45 | 84 (38, 140) mg/l | 5654 | 2356 | 719 | 1014 | 1565 | 0.77 [0.73, 0.81] | 0.75 [0.69, 0.79] | 0.67 [0.58, 0.74] |
| IL-6 | 22 | 138 (75, 220) pg/ml | 3450 | 1376 | 403 | 625 | 1046 | 0.79 [0.75, 0.82] | 0.72 [0.63, 0.80] | 0.73 [0.67, 0.79] |
| sTREM-1 | 8 | 123 (635, 594) pg/ml | 831 | 406 | 82 | 126 | 217 | 0.85 [0.82, 0.88] | 0.78 [0.66, 0.87] | 0.78 [0.65, 0.87] |
| Presepsin | 9 | 600 (415, 647) pg/ml | 1510 | 777 | 155 | 168 | 410 | 0.88 [0.85, 0.90] | 0.84 [0.79, 0.88] | 0.77 [0.68, 0.84] |
| LBP | 5 | 30 (24.35, 32) μg/ml | 1136 | 305 | 208 | 191 | 432 | 0.71 [0.67, 0.75] | 0.62 [0.53, 0.71] | 0.70 [0.59, 0.79] |
| CD64 | 4 | – | 558 | 300 | 13 | 76 | 169 | 0.96 [0.94, 0.97] | 0.87 [0.75, 0.94] | 0.93 [0.87, 0.96] |
TP true positive, FP false positive, FN false negative, TN true negative
aMedian (25% percentiles, 75% percentiles)