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. 2016 Dec 13;6:91. doi: 10.1186/s13550-016-0243-2

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 1 — Production of [¹⁸F]exendin-4. ¹⁸F-fluoride (aqueous) and tosylate (1) were combined in a nucleophilic reaction for ¹⁸F-prelabeling; the product, ¹⁸F-fluoro-propargyl-triethylene glycol, was attached to exendin-4-azide (2) via Cu(I)-catalyzed alkyne/azide cycloaddition to produce radiofluorinated exendin-4