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. 2016 Dec 13;6:91. doi: 10.1186/s13550-016-0243-2

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 3 — Ex vivo measurements of accumulation of exendin-based PET and SPECT tracers in rat kidney. The renal clearance of [¹⁸F]exendin-4 (blue) was rapid, and the radioactivity in kidney was significantly lower at all investigated time points, compared to other, metal-labeled, exendin-based tracers designed for PET and SPECT analyses [2, 3, 41]. Ex vivo autoradiography images (blue inset) show the decreasing [¹⁸F]exendin-4 accumulation in the kidney cortex at 60, 120, and 360 min p.i.