Table 1.
Characteristics of CF patients chronically infected with Ralstonia mannitolilytica and outcomes after first identification of RM strains in their respiratory tracts.
| Patient no | 1 | 2 | 3 | 4 | 5 | 6 | 7 |
|---|---|---|---|---|---|---|---|
| CF mutation | ΔF508/ΔF508 | ΔF508/621+1G→T | 621+1G→T/G542X | ΔF508/ΔF508 | ΔF508/A455E | ΔF508/I148T | ΔF508/ΔF508 |
| Gender | F | F | F | F | F | M | M |
| Date of 1st isolation (age) | Nov 7, 2008 (27) | Sept 4, 2004 (29) | Mar 5, 2009 (28) | Aug 25, 2008 [19] | Sept 14, 2011 (39) | Nov 26, 2008 [21] | Jul 16, 2008 (37) |
| RM strains isolated | 2 RM strainsa | 3 RM strains | 1 RM straina | 1 RM strain | 1 RM straina | 1 straina | 2 strainsa |
| Other organisms |
B. cepacia P. aeruginosa MS S. aureus S. maltophilia A. xylosoxidans A. fumigatus |
R. picketti MR S. aureus |
P. aeruginosa MR S. aureus A. xylosoxidans |
P. aeruginosa MR S.aureus A. fumigatus |
P. aeruginosa |
P. aeruginosa MR S. aureus MS S. aureus |
P. aeruginosa MR S. aureus |
| IV antibiotic courses | 21 | 11 | 16 | 3 | 1 | 6 | 2 |
| Cumulative hospital days | 354 | 457 | 525 | 84 | 14 | 362 | 56 |
| Cause of death | N/A | Multilobar pneumonia | Hypoxemic CRA | RM septic shock, lung abscess | RM septic shock | Multilobar pneumonia | Pneumonia |
| Date of death | N/A | Mar 12, 2009 | Jan 12, 2013 | Dec 3, 2008 | Sept 26, 2011 | Feb 13, 2011 | Sept 13, 2008 |
| Survival with RM (days) | ongoing | 1638 | 1409 | 100 | 12 | 809 | 59 |
a
Based on the biochemical, morphological and antibiotic resistance observed in the clinical microbiological laboratory; RM: Ralstonia manninolitytica; B. cepacia: Burkholderia cepacia; P. aeruginosa: Pseudomonas aeruginosa; MS S. aureus: Multi sensitive Staphylococcus aureus; S. maltophilia: Stenotrophomonas maltophilia; A. xylosoxidans: Achromobacter xylosoxidans; A. fumigatus: Aspergillus fumigatus; R. picketti: Ralstonia picketti; MR S. aureus: Methicillin resistant Staphylococcus aureus; CRA: Cardiorespiratory arrest.