Table 2.
Comparison of parameters before and after receiving vitamin D supplements in patients with pulmonary artery hypertension and vitamin D deficiency
| Parameters |
Before
N=22 |
After
N=21 |
P value |
|---|---|---|---|
| serum vitamin D level (ng/ml) | 14.4(9.2) | 69.2(31) | <0.001* |
| serum Pro-BNP level (ng/ml) | 436(47.6) | 486(60.7) | 0.66* |
| 6MWT(meter) | 259.9(124.3) | 330.5(139.2) | <0.001* |
| Pre6MWTO2Sat (%) | 90.7(8.9) | 90.5(8.4) | 0.81* |
| Post6MWT O2Sat (%) | 87.7(8.9) | 88.9(9.4) | 0.29* |
| EF (%) | 53.8(3.9) | 55.2(4) | 0.14* |
| Peak-PAP(mmHg) | 93.4(20.4) | 92.41(24.8) | 0.81* |
| Mean-PAP(mmHg) | 79.75(24.92) | 69.5(23.04) | 0.07* |
| Functional Class (number (%)) | 0.22** | ||
| I II III IV |
0 9(41%) 11(50%) 2(9%) |
0 12(55%) 9(41%) 0 |
|
| RV size (number (%)) | 0.01** | ||
| Preserved Mild enlargement Moderate enlargement Severe enlargement |
1(4.5%) 2(9%) 5(22.7%) 14(63.8%) |
2(9%) 4(19.1%) 5(23.8%) 10(48.1%) |
|
| RV Function (number (%)) | 0.29** | ||
| Normal Mild dysfunction Moderate dysfunction Severe dysfunction |
4(18.3%) 6(27.3%) 8(36.1%) 4(18.3%) |
6(28.5%) 6(28.5%) 6(28.5%) 3(14.5%) |
Data are presented as mean (Standard deviation) and number (%); 6MWT: Six Minute Walk Test; O2Sat: Oxygen Saturation; EF: Ejection Fraction; PAP: Pulmonary Artery Pressure; Function class I = without limitation of physical activity, class II = slight limitation of physical activity, class III= marked limitation of physical activity, class IV = inability to carry on any physical activity without discomfort; RV: Right Ventricle;
*
Paired t-test;
* *
Wilcoxon test;