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. 2016 Dec 13;7:589. doi: 10.3389/fimmu.2016.00589

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Copyright © 2016 Boesch, Osei-Owusu, Crowley, Chu, Chan, Weiner, Bharadwaj, Hards, Adamo, Gerber, Cocklin, Schmitz, Miles, Eckman, Belli, Reimann and Ackerman.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Characterization of natural killer (NK) cell degranulation activity of Macaca mulatta (MM) immunoglobulin G (IgG) subclasses and comparison to human IgG subclasses. (A) Subclass-switched forms of the human VRC01 mAb were evaluated in for ability to drive degranulation of NK-92 cells by directly coating a dilution series of IgG onto a 96-well plate. (B) Recombinant rhesus macaque IgG (MM1–4) and polyclonal rhesus macaque plasma IgG (pIgG) was likewise evaluated. Results from an assay with less responsive (left, n = 1) or normally responsive NK-92 cells (right, n = 4) are presented.