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. 2016 Dec 13;7:589. doi: 10.3389/fimmu.2016.00589

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Copyright © 2016 Boesch, Osei-Owusu, Crowley, Chu, Chan, Weiner, Bharadwaj, Hards, Adamo, Gerber, Cocklin, Schmitz, Miles, Eckman, Belli, Reimann and Ackerman.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Characterization of the phagocytic activity of Macaca mulatta (MM) immunoglobulin G (IgG) subclasses and comparison to human IgG subclasses. (A) Exemplary flow cytometry histograms for a titration of MM IgG1 driving phagocytosis of CD8α-conjugated fluorescent beads. (B) Myeloma-derived human IgG1–4 were evaluated in the same assay measuring uptake of fluorescent beads, in this case using beads conjugated with an anti-human Fab reagent. Results from one representative experiment with technical replicates are presented. (C) Recombinant monoclonal rhesus macaque IgG (MM IgG1–4) was evaluated for its ability to drive phagocytosis of CD8α-conjugated fluorescent beads. Representative results from two of five independent experiments in which duplicate titrations were assessed are presented.