Table 1.

Relative Fc sequence conservation across species.

	MM IgG1	MM IgG2	MM IgG3	MM IgG4
CH1–hinge–CH2–CH3
Hu IgG1	90.7	88.5	89.2	88.8
Hu IgG2	87.1	88.3	87.7	88.1
Hu IgG3	78.5	76.4	78.2	76.4
Hu IgG4	87.4	87.2	89.2	90.2
MM IgG1	–	89.8	91	89.2
CH2
Hu IgG1	90.0	89.1	90.9	92.7
Hu IgG2	82.7	84.5	88.2	90.0
Hu IgG3	87.3	87.3	89.1	90.9
Hu IgG4	85.5	86.4	91.8	93.6
MM IgG1	–	90.9	92.7	90.9

Matrix presents the percent identity between the entire Fc and within the CH2 domain only.