. 2016 Dec 13;7:589. doi: 10.3389/fimmu.2016.00589

Table 2.

Affinity of Macaca mulatta (MM) immunoglobulin G (IgG) subclasses for low affinity human FcγR.

	FcγR	MM IgG1	MM IgG2	MM IgG3	MM IgG4
Experiment 1	FcγRIIa H131	7 ± 1	11 ± 4	27 ± 9	23 ± 5
	FcγRIIa R131	9 ± 4	32 ± 7	11 ± 2	11 ± 2
	FcγRIIb/c	36 ± 7	90 ± 43^a	46 ± 12^a	33 ± 3
	FcγRIIIa V158	4 ± 2	21 ± 13	84 ± 84^a	32 ± 11^a
	FcγRIIIa F158	4 ± 1	48 ± 51^a	78 ± 52^a	48 ± 26^a
	FcγRIIIb NA1	18 ± 7	700 ± 430^a	700 ± 430^a	500 ± 370^a
	FcγRIIIb NA2	13 ± 5	400 ± 420^a	510 ± 370^a	730 ± 380^a
	FcγRIIIb SH	15 ± 8	530 ± 340^a	740 ± 370^a	465 ± 400^a
Experiment 2	FcγRIIa H131	9 ± 2	11 ± 4	16 ± 4	20 ± 10
	FcγRIIa R131	21 ± 9	41 ± 16^a	25 ± 20	20 ± 6
	FcγRIIb/c	53 ± 14^a	125 ± 37^a	38 ± 7	32 ± 7^a
	FcγRIIIa V158	5 ± 2	14 ± 11	27 ± 33	29 ± 17
	FcγRIIIa F158	8 ± 2	15 ± 4	33 ± 4^a	17 ± 1
	FcγRIIIb NA1	14 ± 6	250 ± 320^a	210 ± 170^a	120 ± 80^a
	FcγRIIIb NA2	15 ± 3	32 ± 2^a	270 ± 420^a	270 ± 67^a
	FcγRIIIb SH	9 ± 4	80 ± 100^a	350 ± 860^a	340 ± 500^a

Binding affinities (K_D) of MM IgG subclasses for low affinity human FcγR allotypic variants as determined by surface plasmon resonance. Data are reported as the mean in micromolar ± SD across at least three independent measurements.

^aValue is outside of the concentration range used and is therefore less reliable.