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. 2016 Dec 6;111(11):2440–2449. doi: 10.1016/j.bpj.2016.10.016

Figure 4.

Figure 4

Representative aggregation curves of αS truncated variants. The αS truncated variants were aggregated in the presence (open symbols) and absence (solid symbols) of 1:1 POPC:POPG liposomes. 1-108-αS (green downward triangles) aggregated with a lag-time of ∼3 h whereas the lag time of the WT-αS (black squares) was ∼25 h 50 μM of protein of each variant in at least six replicates were allowed to aggregate in 50 mM HEPES, 0.1 mM EDTA (pH 7.4) buffer at 37°C at 300 rpm in a fluorescence plate reader. ThT concentration was kept constant at 10 μM. To see this figure in color, go online.