Table 5. PRP application in the clinic.
| Sample size (patients) | Treatment | Time | Outcome | References |
|---|---|---|---|---|
| 44 | Open-wedge high tibia osteotomy (HTO) with or without Human MSC therapy and PRP injection. | 24–36 months | The MSC-PRP group showed significantly greater improvements in the KOOS subscales for pain and symptoms. Arthroscopic evaluation, at plate removal, showed that partial or even fibrocartilage coverage was achieved in 50% of the MSC-PRP group patients but in only 10% of the patients in the PRP-only group (P<0.001). | 231 |
| 24 | Delayed fracture union: PRP, sorted Human MSCs in suspension and DBM (Ignite ICS injectable scaffold) | 2, 6 weeks, 3, 6, 9 and 12 months. | No significant difference in VAS (visual analog scale), at 6-month time point, all fractures in the intervention group had healed, 25% of the control group experienced delayed union as their fractures did not unite by the 3-month follow-up. | 232 |
| 72 | Bone non-union: 6–8 mL platelet-rich plasma prepared by centrifugalizing venous blood and MSCs extracted from human umbilical cord. | 2 years | No loosening and breakage of internal fixation were observed in two groups at 2 years. The motility and function of hip, knee and ankle were good. Significantly higher healing rate in MSC+PRP group. | 233 |
| 6 | Human MSC+PRP −972 269 (range 524 480–2 033 000) in sinus augmentation and alveolar ridge augmentation. | 6 months | At 6 months after loading, as tested after removal of the prosthetic reconstruction, all implants maintained stability. Marginal bone resorption at 6 months after loading did not exceed 1.5 mm. | 234 |
| 23 | Injectable Human BMSCs and autologous PRP | 3, 6 months and 1 year | Increased bone formation and Osseointegration.The mean regenerated bone height was 8.2±1.6 mm and 8.0±1.4 mm, and the average alveolar bone height was 15.6±1.2 mm and 15.1±1.4 mm, at 3 and 6 months, respectively. There were significant differences between pre-operative values and post-operative ones (at 3 and 6 months). No perforations of the Schneider membrane were found and the inserted implants were successful after 1 year. | 235 |
| 01 | Human MSCs and PRP | 6 months | Re-examination at 6 months demonstrated that the application of MSCs-PRP gel at periodontal sites with angular defects, resulted in a 4-mm reduction in probing depths and a 4-mm clinical attachment gain, while bleeding and tooth mobility disappeared. Radiographic assessments showed that the bone defect had been reduced in depth. | 236 |
Abbrevations: BMSC, bone marrow-derived mesenchymal stem cell; DBM, demineralized bone matrix; MSC, mesenchymal stem cell; PRP, platelet-rich plasma.