Table 2.
Volume of subcortical structures.
Healthy controls | sALS | C9 + (all) | C9 + subtypes |
||||
---|---|---|---|---|---|---|---|
Asymp. | ALS | bvFTD | ALS-FTD | ||||
Cerebellum | 8.65 ± 0.77 | 8.28 ± 0.91 | 8.46 ± 0.91 | 9.22 ± 0.74 | 8.64 ± 0.72 | 7.94 ± 0.36 | 7.53 ± 0.65 |
Thalamus | 0.98 ± 0.11 | 0.91 ± 0.10 | 0.88 ± 0.12a | 1.01 ± 0.08 | 0.90 ± 0.07 | 0.76 ± 0.09a | 0.77 ± 0.09a |
Caudate | 0.50 ± 0.06 | 0.51 ± 0.06 | 0.47 ± 0.08 | 0.49 ± 0.07 | 0.52 ± 0.07 | 0.38 ± 0.07 | 0.41 ± 0.05 |
Putamen | 0.72 ± 0.10 | 0.70 ± 0.11 | 0.67 ± 0.15 | 0.78 ± 0.09 | 0.72 ± 0.11 | 0.51 ± 0.12 | 0.53 ± 0.10 |
Pallidum | 0.20 ± 0.03 | 0.21 ± 0.03 | 0.19 ± 0.04 | 0.21 ± 0.03 | 0.21 ± 0.03 | 0.14 ± 0.02 | 0.15 ± 0.03 |
Volumes are expressed as % of total intracranial volumes. sALS = sporadic ALS, Asymp = C9 + asymptomatic carriers.
Less than controls, p < 0.05, Dunnett's test, corrected for multiple comparisons.