Table 3.

Thickness of selected cortical regions at the baseline scan.

	Left hemisphere				Right hemisphere
	Healthy controls (n = 28)	C9 + subjects (all) (n = 27)	Sporadic ALS (n = 22)	Sig	Healthy controls (n = 28)	C9 + subjects (all) (n = 27)	Sporadic ALS (n = 22)	Sig
Mean thickness (hemisphere)	2.45 ± 0.09	2.33 ± 0.16	2.44 ± 0.11	A, B	2.44 ± 0.09	2.33 ± 0.17	2.43 ± 0.12	A, B
Precentral	2.56 ± 0.17	2.44 ± 0.21	2.40 ± 0.16		2.55 ± 0.16	2.40 ± 0.23	2.34 ± 0.19	B, C
Paracentral	2.44 ± 0.14	2.32 ± 0.18	2.37 ± 0.23		2.43 ± 0.14	2.28 ± 0.18	2.39 ± 0.20
Postcentral	2.12 ± 0.12	2.05 ± 0.16	1.99 ± 0.13		2.10 ± 0.14	2.01 ± 0.21	1.97 ± 0.16
Insula	2.95 ± 0.16	2.88 ± 0.21	2.94 ± 0.16		2.91 ± 0.15	2.83 ± 0.21	2.92 ± 0.18
Lateral orbitofrontal	2.45 ± 0.12	2.38 ± 0.21	2.60 ± 0.12	A	2.41 ± 0.11	2.34 ± 0.18	2.49 ± 0.16	A, C
Medial orbitofrontal	2.37 ± 0.12	2.35 ± 0.21	2.35 ± 0.19		2.30 ± 0.12	2.26 ± 0.18	2.48 ± 0.17	A
Rostral middle frontal	2.30 ± 0.09	2.18 ± 0.18	2.32 ± 0.10	A, B	2.25 ± 0.09	2.16 ± 0.17	2.32 ± 0.13	A
Superior frontal	2.59 ± 0.09	2.47 ± 0.23	2.70 ± 0.13	A	2.56 ± 0.10	2.42 ± 0.19	2.68 ± 0.15	A, B
Caudal middle frontal	2.47 ± 0.09	2.35 ± 0.19	2.49 ± 0.12	A, B	2.45 ± 0.11	2.38 ± 0.19	2.44 ± 0.15
Lateral occipital	2.20 ± 0.11	2.07 ± 0.14	2.20 ± 0.15		2.24 ± 0.13	2.14 ± 0.15	2.27 ± 0.14	A
Fusiform	2.74 ± 0.14	2.61 ± 0.21	2.65 ± 0.15		2.73 ± 0.15	2.58 ± 0.21	2.64 ± 0.14	B
Middle temporal	2.84 ± 0.16	2.72 ± 0.22	2.84 ± 0.20		2.80 ± 0.14	2.71 ± 0.20	2.88 ± 0.19	A
Inferior parietal	2.42 ± 0.10	2.30 ± 0.16	2.45 ± 0.16	A, B	2.42 ± 0.13	2.32 ± 0.18	2.43 ± 0.14

Means ± SD. Sig = significant differences, corrected for age and multiple comparisons p < 0.05.

A: C9 + < sALS, B: C9 + < HC, C: sALS < HC.