Table 3.
Right MTLE-HS group voxel-based analysis.
|
18F-FDG-PET hypometabolism |
Decreased fractional anisotropy (FA) |
Increased mean diffusivity (MD) |
||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Anatomical region |
Cluster size (mm3) |
Cluster level p corrected | MNI coordinates |
t statistic | Anatomical region |
Cluster size (mm3) |
Cluster level p corrected | MNI coordinates |
t statistic | Anatomical region |
Cluster size (mm3) |
Cluster level p corrected | MNI coordinates |
t statistic | ||||||
| x | y | z | x | y | z | x | y | z | ||||||||||||
| R Insula | 451 | 0.05(FWE) | 34 | 22 | − 16 | 17.07 | R EC | 120 | 0.001 | 32 | 14 | 6 | 10.36 | R EC | 144 | 0.001 | 36 | 6 | − 10 | 7.24 |
| R inf F g (opercular) |
318 | 0.05(FWE) | 56 | 34 | 2 | 14.57 | R IFO/Unc | 355 | 0.05(FWE) | 50 | 40 | 8 | 14.08 | R IFO/Unc | 256 | 0.001 | 52 | 20 | 14 | 7.28 |
| L inf F g (opercular) |
204 | 0.05(FWE) | − 52 | 36 | 10 | 13.89 | L IFO/Unc | 133 | 0.001 | − 52 | 30 | − 4 | 10.49 | L IFO/Unc | 89 | 0.001 | − 53 | 10 | 20 | 6.27 |
| R Temporal lobe | 976 | 0.05(FWE) | 60 | 2 | − 30 | 12.60 | R ILF/SLF | 1169 | 0.05(FWE) | 64 | − 20 | 4 | 17.61 | R ILF/SLF | 976 | 0.05(FWE) | 30 | 4 | − 32 | 12.42 |
| R Postcentral g | 68 | 0.001 | 26 | − 32 | 58 | 9.77 | L Cortical-spinal tract | 415 | 0.001 | 22 | − 26 | 48 | 7.25 | R post Cing | 65 | 0.001 | 10 | − 22 | 32 | 7.38 |
| L Precentral g | 36 | 0.001 | − 48 | 22 | 38 | 9.27 | L Cortical-spinal tract | 378 | 0.001 | − 24 | − 22 | 34 | 6,97 | L post Cing | 52 | 0.001 | − 8 | − 22 | − 29 | 7.16 |
| R Prec/post Cing | 798 | 0.001 | 14 | − 60 | 16 | 8.34 | R Corona Radiata | 258 | 0.001 | 48 | − 38 | 32 | 6.66 | |||||||
| R T-O | 35 | 0.001 | 58 | − 60 | − 22 | 7.80 | R IFO/forceps mayor | 516 | 0.05 (FWE) | 20 | − 80 | 10 | 14.91 | R CC (Splenium)/forceps mayor | 148 | 0.001 | 10 | − 24 | 28 | 7.02 |
| L T-O | 126 | 0.001 | − 50 | − 76 | − 12 | 13.11 | L IFO/forceps mayor | 626 | 0.05 (FWE) | − 18 | − 90 | 12 | 14.44 | L CC (Splenium)/forceps mayor | 145 | 0.001 | − 18 | − 44 | 22 | 7.03 |
| R, L CC (ant)/forceps minor | 369 | 0.001 | 4 | 18 | 20 | 8.59 | ||||||||||||||
| L EC | 87 | 0.001 | − 27 | 42 | 10 | 6.86 | ||||||||||||||
| L corona radiata | 186 | 0.001 | − 34 | − 52 | 16 | 6.34 | ||||||||||||||
L, left; R, right; Inf, inferior; Ant, anterior; Post, posterior; F, frontal; G, gyrus; T-O: temporo-occipital; Prec, precuneus; Cing, cingulum; EC, external capsule; CC, corpus callosum; Unc, Uncinate fasciculus; IFO: inferior fronto-occipital fasciculus; SLF, superior longitudinal fasciculus; ILF, inferior longitudinal fasciculus; FWE: family-wise error; MTLE, mesial temporal lobe epilepsy; HS, hippocampal sclerosis; MNI, Montreal Neurological Institute and Hospital.