Figure 1.

HCRP1 is a possible mammalian counterpart of yeast Vps37. (A) Domain structure of Vps37 (NP_013220) and HCRP1 (AAK54349) is shown. The regions that are most conserved between these proteins are shaded, with the calculated sequence identity indicated. These conserved regions contain a modifier of rudimentary [mod(r)] domain (pfam: PF07200) (light gray), which is found in several eukaryotic proteins. These include three additional human protein products, FLJ20847 (hVps37C), FLJ12750 (hVps37B), and Wbscr24 (hVps37D), which are shown in the figure. The mod(r) domain of CAD38936 (the partial sequence of FLJ20847) includes the residues (26–175) (see Materials and Methods). (B) Alignment of the conserved region between Vps37 and HCRP1 is shown. The rat counterpart (XP_214353) of HCRP1 also is included. The starting point of the mod(r) domain is indicated.