Table 1. Fraction of XBP-1 mRNA splicing as a percentage of total XBP-1 mRNA in bystander HL-7702 cells treated with Thapsigargin, BiP siRNA, or their combination before receiving ICCM from normoxic and hypoxic HepG2 cells. Data were calculated from the results in Fig. 5a and b.
Treatment | O2- Irradiated Conditioned Medium |
N2- Irradiated Conditioned Medium |
||
---|---|---|---|---|
0 Gy | 3 Gy | 0 Gy | 3 Gy | |
Control | 0 | 0 | 0 | 0 |
Thapsigargin | 0.266 ± 0.0013a | 0.270 ± 0.0052a | 0.396 ± 0.0026a | 0.396 ± 0.0014a |
Control siRNA | 0 | 0 | 0 | 0 |
BiP siRNA | 0 | 0 | 0 | 0 |
BiP siRNA+ Thapsigargin | 0.685 ± 0.0074b,c | 0.658 ± 0.0030b,c | 0.688 ± 0.0052b,c | 0.674 ± 0.0072b,c |
aP < 0.001 compared to control receiving the same ICCM.
bP < 0.001 compared to BiP siRNA receiving the same ICCM.
cP < 0.001 compared to Thapsigargin receiving the same ICCM.