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. 2016 Dec 13;6:38881. doi: 10.1038/srep38881

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Method groups categorized according to the normalization performances across various sample sizes based on four benchmark datasets: (a) MTBLS28 ESI+, (b) MTBLS28 ESI−, (c) MTBLS17 ESI+ and (d) MTBLS17 ESI−. (G–A) superior performance group; (G-B1) good performance group including methods occasionally classified to top green area of Fig. 3; (G-B2) good performance group including methods consistently staying in middle blue area of Fig. 3; (C) poor performance group. All lines were generated by the LOESS regression.