Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Dec 12;18:291. doi: 10.1186/s13075-016-1189-5

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

Fig. 4 — Effects of HA and adelmidrol combination on plasma levels of matrix metalloproteinases (MMPs). MMPs play a primary role in the downstream signaling pathways in osteoarthritis (OA) and cartilage degradation. The MIA + vehicle and 1% sodium hyaluronate group showed a markedly higher expression of MMP-1 (a), MMP-3 (b), and MMP-9 (c). Compared to the MIA group, the group treated with 0.6% adelmidrol + 1.0% sodium hyaluronate and, in particular, with 2% adelmidrol + 1.0% sodium hyaluronate showed a decrease in MMP-1, MMP-3, and MMP-9 expression (a–c, respectively). Data are means ± SEM of 10 rats for each group. *P < 0.05 versus sham, °P < 0.05 versus MIA + vehicle