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. 2016 Dec 12;16:141. doi: 10.1186/s12876-016-0557-6

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Association between changes in histopathological score [a ΔSteatosis, b ΔBallooning, c ΔLobular inflammation, and d ΔStage] with logarithmically transformed serum miR-122 ratio. Changes in histopathological scores (Δ) represented the value at second liver biopsy minus value at first liver biopsy. Serum miR-122 ratio was calculated by (ratio at serum miR-122 level at second liver biopsy/ratio at serum miR-122 level at first liver biopsy). Note the strong associations (r ≥ 0.5) between serum miR-122 ratio and changes in histopathological scores [a ΔSteatosis, c ΔLobular inflammation, and d ΔStage]