Fig. 3.

PET images and representative histopathology for a range of subjects including some disparity cases (PET images are representative Rainbow colour scale, axial and parasagittal slices. BIE status and results for the 5 readers (N = normal, A = abnormal). A representative photomicrograph of β-amyloid IHC (frontal lobe) with % area (if determined), representative photomicrograph of Bielschowsky silver stain (frontal lobe) and Bielschowsky score (original magnification 100x for both); Braak stage of neurofibrillary tangles and overall neuropathological diagnosis, including AD likelihood (NIA-RI criteria). Note: the photomicrographs of the frontal lobe may not accurately represent the pathology of other regions