Table 5.

Summary statistics and case status for each of the β-amyloid dichotomy algorithms

	Case status (5 readers per case)				Pathology
Reference standard	TN	FP	FN	TP	Normal	Abnormal	Sensitivitya	Specificityb
mCERADSOT c	131	19	33	347	30	76	91%	87%
mCERADmode d	134	26	30	340	32	74	92%	84%
CERADe	134	51	30	315	37	69	91%	72%
Amyloid phasef	108	2	56	364	22	84	87%	98%

TN true negative, FP false positive, FN false negative, TP true positive

^asensitivity (true positive rate) = TP/(TP + FN)

^bspecificity (true negative rate) = TN/(TN + FP)

^cAbnormal defined as any regional mCERAD_SOT score > 1.5). Note while these analyses are presented by individual reads, the a priori analysis was by majority read (sensitivity was 91% and specificity was 90% by majority read N = 106)

^dAbnormal defined as any CERAD region moderate or frequent (multiple measures)

^eAbnormal defined as and CERAD region moderate or frequent (single point estimate)

^fAbnormal defined as phase 3, 4 or 5