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. 2016 Dec 13;18:295. doi: 10.1186/s13075-016-1186-8

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Early longitudinal changes in the three cohorts. Changes in mean clinical and functional scores over the first year from recruitment for 28-joint Disease Activity Score (DAS28) (a, b, c), Health Assessment Questionnaire (HAQ) (d, e, f) and 36-item Short Form Health Survey (SF-36) physical function (g, h, i), stratified by latent class subgroup. Cohorts displayed are the Early Rheumatoid Arthritis Network (ERAN) (a, d, g), British Society for Rheumatology Biologics Registers (BSRBR) tumour necrosis factor (TNF) inhibitor (b, e, h) and BSRBR non-biologic (c, f, i). BL Baseline, 6 m 6 months, 1y 1 year. Complete cases were analysed, yielding respective sample sizes for ERAN, BSRBR TNF inhibitor and BSRBR non-biologic for DAS28 (n = 383, 6376 and 887, respectively), HAQ (n = 447, 5627 and 1601, respectively) and SF-36 physical function (n = 217, 6179 and 1706, respectively). There was significant heterogeneity between the changes in scores of all of the latent classes for each cohort and for each measure (p < 0.001 for each comparison)