Table 3. Univariate analysis of factors associated with OS and DFS.
| OS |
DFS |
|||||
|---|---|---|---|---|---|---|
| p value | HR | 95% CI | p value | HR | 95% CI | |
| Age | 0.160 | 1.015 | 0.994-1.036 | 0.075 | 1.019 | 0.998–1.039 |
| Male | 0.023* | 0.566 | 0.346–0.925 | 0.619 | 0.900 | 0.595–1.361 |
| Education | 0.777 | 1.063 | 0.698–1.619 | 0.250 | 1.262 | 0.849–1.877 |
| High school and below | ||||||
| Income | ||||||
| <1000 RMB/month | 0.336 | Ref. | 0.571 | Ref. | ||
| 1000~2000 | 0.152 | 1.330 | 0.900–1.964 | 0.957 | 0.989 | 0.664–1.474 |
| >2000 | 0.320 | 1.208 | 0.833–1.753 | 0.356 | 1.183 | 0.828–1.690 |
| BMI | 0.558 | 0.985 | 0.937–1.036 | 0.906 | 1.003 | 0.954–1.054 |
| Physical activity | <0.001* | 0.942 | 0.916–0.968 | <0.001* | 0.946 | 0.920–0.972 |
| Sun exposure | 0.691 | 1.074 | 0.754–1.530 | 0.907 | 0.980 | 0.696–1.379 |
| <7 days/week | ||||||
| Smoking | 0.991 | 1.002 | 0.730–1.375 | 0.626 | 1.081 | 0.791–1.476 |
| <20 pack-year | ||||||
| Alcohol | 0.299 | 0.831 | 0.587–1.178 | 0.310 | 0.837 | 0.593–1.180 |
| ≤0.025 kg/d | ||||||
| Fruit and vegetable | 0.318 | 0.852 | 0.622–1.167 | 0.364 | 0.866 | 0.635–1.181 |
| ≥300 g/d &≥200 g/d | ||||||
| Fat intake | ||||||
| High | 0.526 | Ref. | 0.397 | Ref. | ||
| Medium | 0.354 | 1.218 | 0.803–1.848 | 0.700 | 0.926 | 0.626–1.370 |
| Low | 0.903 | 1.028 | 0.656–1.613 | 0.205 | 0.760 | 0.497–1.161 |
| Past medical history | ||||||
| HBP | 0.672 | 1.089 | 0.735–1.613 | 0.409 | 0.840 | 0.556–1.271 |
| CAD | 0.687 | 0.877 | 0.462–1.664 | 0.855 | 0.944 | 0.512–1.742 |
| Diabetes | 0.981 | 0.991 | 0.464–2.114 | 0.991 | 0.996 | 0.467–2.124 |
| Tumor information | ||||||
| Pathology | 0.026* | 1.798 | 1.071–3.017 | 0.003* | 2.172 | 1.311–3.598 |
| SCC | ||||||
| Histological grade | ||||||
| Well | 0.118 | Ref. | 0.452 | Ref. | ||
| Moderately | 0.299 | 1.316 | 0.784–2.209 | 0.762 | 0.930 | 0.582–1.487 |
| Poorly/undifferentiated | 0.054 | 1.636 | 0.992–2.699 | 0.536 | 1.153 | 0.735–1.809 |
| Location | 0.792 | 0.958 | 0.696–1.319 | 0.548 | 0.908 | 0.662–1.245 |
| Cervical/upper/middle | ||||||
| Length<3 cm | <0.001* | 0.430 | 0.305–0.607 | <0.001* | 0.540 | 0.391–0.747 |
| T category | ||||||
| 0 | 0.016* | 0.076 | 0.009–0.615 | 0.056 | 0.259 | 0.065–1.038 |
| 1 | <0.001* | 0.115 | 0.041–0.317 | 0.001* | 0.207 | 0.078–0.546 |
| 2 | 0.013* | 0.363 | 0.163–0.806 | 0.103 | 0.494 | 0.211–1.153 |
| 3 | 0.118 | 0.542 | 0.251–1.169 | 0.238 | 0.607 | 0.265–1.391 |
| 4 | <0.001* | Ref. | 0.002* | Ref. | ||
| TNM stage | <0.001* | 2.905 | 2.116–3.990 | <0.001* | 2.452 | 1.793–3.355 |
| 0/I/II | ||||||
| Lymph node metastasis | <0.001* | 2.771 | 2.002–3.836 | <0.001* | 2.093 | 1.531–2.860 |
| No. of metastatic lymph nodes | <0.001* | 1.131 | 1.089–1.174 | <0.001* | 1.164 | 1.113–1.218 |
| Ratio of lymph node<0.2 | <0.001* | 0.393 | 0.279–0.553 | <0.001* | 0.418 | 0.293–0.597 |
| Type of surgery | ||||||
| Left-thoracic esophagectomy | 0.305 | 1.226 | 0.831–1.807 | 0.263 | 1.251 | 0.845–1.852 |
| Treatment regimen | ||||||
| S | 0.013* | Ref. | 0.004* | Ref. | ||
| S plus postoperative R | 0.003* | 2.129 | 1.287–3.522 | 0.042* | 1.774 | 1.020–3.085 |
| S plus postoperative C | 0.155 | 1.358 | 0.891–2.070 | 0.098 | 1.419 | 0.937–2.149 |
| S plus postoperative CRT | 0.040* | 1.555 | 1.020–2.370 | 0.001* | 1.976 | 1.327–2.942 |
| Vitamin D supplementation | 0.308 | 0.795 | 0.511–1.237 | 0.035* | 0.611 | 0.386–0.966 |
HR, hazard ratio; CI, confidence interval; BMI, body mass index; HBP, high blood pressure; CAD, coronary artery disease; SCC, squamous cell carcinoma; S, surgery; R, radiotherapy; C, chemotherapy; CRT, chemoradiotherapy. *p < 0.05.