Table 4. Multivariate analysis of factors associated with OS and DFS.
| OS |
DFS |
|||||
|---|---|---|---|---|---|---|
| p value | HR | 95% CI | p value | HR | 95% CI | |
| Male | 0.132 | 0.675 | 0.404–1.126 | — | — | — |
| Physical activity | 0.004* | 0.957 | 0.928–0.986 | <0.001* | 0.949 | 0.922–0.978 |
| Pathological type | 0.589 | 1.169 | 0.663–2.061 | 0.059 | 1.682 | 0.981–2.883 |
| SCC | ||||||
| Length<3 cm | 0.096 | 0.729 | 0.503–1.058 | 0.095 | 0.733 | 0.509–1.056 |
| T category | ||||||
| 0 | 0.186 | 0.230 | 0.026–2.034 | 0.935 | 1.066 | 0.227–5.011 |
| 1 | 0.022* | 0.253 | 0.078–0.817 | 0.530 | 0.686 | 0.212–2.220 |
| 2 | 0.304 | 0.606 | 0.233–1.576 | 0.630 | 1.325 | 0.459–3.822 |
| 3 | 0.423 | 0.703 | 0.297–1.665 | 0.764 | 1.160 | 0.441–3.049 |
| 4 | 0.094 | Ref. | 0.376 | Ref. | ||
| TNM stage | 0.968 | 1.012 | 0.558–1.836 | 0.158 | 1.574 | 0.839–2.955 |
| 0/I/II | ||||||
| Lymph node metastasis | 0.097 | 1.619 | 0.917–2.856 | 0.786 | 0.922 | 0.514–1.655 |
| No. of metastatic lymph nodes | 0.246 | 1.040 | 0.973–1.111 | 0.059 | 1.076 | 0.997–1.161 |
| Ratio of lymph node<0.2 | 0.406 | 0.812 | 0.496–1.327 | 0.993 | 1.002 | 0.593–1.695 |
| Treatment regimen | ||||||
| S | 0.480 | Ref. | 0.158 | Ref | ||
| S plus postoperative R | 0.142 | 1.475 | 0.878–2.480 | 0.323 | 1.336 | 0.752–2.375 |
| S plus postoperative C | 0.831 | 0.952 | 0.608–1.493 | 0.339 | 1.236 | 0.800–1.910 |
| S plus postoperative CRT | 0.964 | 1.010 | 0.650–1.571 | 0.026* | 1.628 | 1.060–2.500 |
| Vitamin D supplementation | — | — | — | 0.040* | 0.610 | 0.381–0.978 |
HR, hazard ratio; CI, confidence interval; SCC, squamous cell carcinoma; S, surgery; R, radiotherapy; C, chemotherapy; CRT, chemoradiotherapy.
*p < 0.05