Table 3.

Peak loci of reduced grey matter density for patients with ePD who are amyloid negative (ePD−) and amyloid positive (ePD+) relative to demographically comparable healthy controls who are amyloid negative (Control−) and direct comparisons relative to each other

Contrast	Cluster size	p Value of cluster maxima (FWE)	MNI coordinates			L/R/M	Neuroanatomical region (Brodmann area)
			X	Y	Z
ePD− <Control−	2135	0.003	52	6	32	R	Precentral gyrus (6)
	1686	0.001	26	−2	−50	R	Perirhinal cortex/temporal pole (38)
	1405	0.003	−18	−6	−24	L	Amygdala
	612	0.006	−6	−38	−52	M	Brainstem
	605	0.005	−46	−20	14	L	Angular gyrus (40/41)
	409	0.002	62	−56	−10	R	Fusiform gyrus (37)
	333	0.006	12	0	68	R	Precentral gyrus (6)
	292	0.005	24	14	−2	R	Putamen
	287	0.005	−58	−28	8	L	Heschl’s gyrus (42)
	202	0.011	−6	−20	8	L	Thalamus
	168	0.012	18	48	42	R	Superior frontal gyrus (8)
	134	0.007	−14	22	−16	L	Putamen
	103	0.004	−38	10	60	L	Precentral gyrus (6)
	75	0.028	−46	−52	−24	L	Fusiform gyrus (36)
	66	0.017	30	−54	−10	R	Fusiform gyrus (37/19)
	62	0.015	−4	−34	74	L	Postcentral gyrus (4)
	57	0.019	26	−90	6	R	Cuneus (17)
ePD+ <Control−	10 851	0.001	−28	−10	−46	L	Perirhinal cortex/temporal pole (38)
	2103	0.001	48	46	−8	R	Middle frontal gyrus (44/46)
	1796	0.001	30	16	−46	R	Perirhinal cortex/temporal pole (38)
	805	0.001	68	−46	4	R	Superior temporal gyrus (22)
	657	0.002	−34	−74	20	L	Angular gyrus (39/19)
	331	0.001	−6	−18	2	L	Thalamus
	296	0.003	−4	−12	34	L	Cingulate gyrus (24/23)
	190	0.013	−24	22	62	L	Precentral gyrus (6)
	101	0.011	−56	−46	38	L	Angular gyrus (40)
	99	0.006	−18	8	−6	L	Putamen
	93	0.024	10	−22	14	R	Thalamus
	92	0.012	36	8	48	R	Precentral gyrus (6)
	85	0.025	54	−46	−20	R	Fusiform gyrus (37)
	79	0.023	50	−64	14	R	Angular gyrus (39/19)
	75	0.019	44	−32	22	R	Intraparietal sulcus (40)
	60	0.026	20	−54	4	R	Lingual gyrus (19)
	52	0.016	64	−12	26	R	Postcentral gyrus (4)
	50	0.021	−48	−26	62	L	Postcentral gyrus (1/2)
	50	0.011	−16	−76	38	L	Cuneus (19)
ePD+ <ePD−	3518	0.001	4	30	−30	R	Rectus gyrus (11)
	547	0.016	−38	−12	−30	L	Middle temporal gyrus (21)
	331	0.003	20	58	16	R	Anterior cingulate cortex (24)
	325	0.007	46	−50	14	R	Middle temporal gyrus (39)
	317	0.004	−36	12	38	L	Dorsolateral prefrontal cortex (9)
	285	0.003	−8	−60	16	L	Posterior cingulate gyrus (23)
	265	0.008	−46	−60	10	L	Middle temporal gyrus (21)
	212	0.01	−6	−20	6	L	Thalamus
	187	0.011	−26	−8	−36	L	Parahippocampal gyrus (36/28)
	139	0.012	−24	−10	52	L	Precentral gyrus (4)
	135	0.013	8	−24	10	R	Thalamus
	132	0.001	−14	−28	38	L	Cingulate gyrus (31)
	102	0.018	16	60	−4	R	Superior frontal gyrus (10)
	63	0.021	38	22	26	R	Dorsolateral prefrontal cortex (9)
	61	0.014	6	38	42	R	Superior frontal gyrus (8)
	60	0.025	−56	−30	30	L	Angular gyrus (40)
	60	0.023	64	−24	−26	R	Fusiform gyrus (20/36)
	60	0.032	28	0	−46	R	Perirhinal cortex/temporal pole (38)
ePD− <ePD+	1120	0.001	14	−14	−14	R	Substantia nigra
	620	0.001	−6	−42	−68	M	Brainstem
	433	0.002	−8	−14	−6	L	Substantia nigra
	65	0.015	−4	−58	64	L	Precuneus (7)

All loci are reported in the MNI stereotactic space using FWE correction (p<0.05) and TFCE.

ePD, early Parkinson’s disease; FWE, family-wise error; L, left; M, medial; MNI, Montreal Neurological Institute; R, right; TFCE, threshold-free cluster enhancement.