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. 2016 Jan 21;7(1):2060. doi: 10.1038/cddis.2015.391

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Copyright © 2016 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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3-(1H-indol-1yl)propan-1-amine (1), three benzimidazole derivatives (2–4), and spinacine (5) inhibit protein–protein interactions. Five compounds at the indicated concentrations (1.4 μM–3.2 mM) were tested using our bead-based screening assay for their ability to inhibit three different protein/protein interactions: (a) GST-E6/His-caspase 8; (b) GST-E6/HisE6AP; and (c) GST-caspase 8/His-caspase 8. Binding in the presence of 1.4 μM of the test compound was set at 100%. Experiments were performed in triplicate, and error bars indicate the S.D.