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. 2016 Jan 21;7(1):2060. doi: 10.1038/cddis.2015.391

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Copyright © 2016 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Myricetin and spinacine (5) increase caspase 3/7 activity in SiHa cells following treatment with TRAIL and chemotherapy drugs. SiHa cells (2 × 10⁴ cells per well) were seeded into a 96-well plate and allowed to incubate overnight and then pretreated with 100 μM of myricetin or 50 μM of spinacine for 4 h. (a) TRAIL (100 ng/ml), along with cycloheximide (5 μg/ml), (b) cisplatin (50 μM), or (c) doxorubicin (2 μM) were added respectively. Caspase 3/7 activity was measured after 0, 1.5, 3, and 6 h using the CellTiter-Glo assay. Activity at 0 h of treatment was set at 100% for each group. Experiments were performed in triplicate, and error bars indicate the S.D.