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. 2016 Jan 21;7(1):2060. doi: 10.1038/cddis.2015.391

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Copyright © 2016 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Myricetin and spinacine (5) can re-sensitize HPV⁺, but not HPV⁻, HNSCC cell lines to treatment with doxorubicin. Two HPV⁻ (UMMSCC 29 and SCC 84) and three HPV⁺ (UMSCC 47, UPCI-SCC90-UP-Clone 35, and UM-SCC47-TC Clone 3) head and neck cancer cell lines (2 × 10⁴ cells per well) were seeded into 96-well plates and allowed to incubate overnight, and then cells were pretreated with myricetin or spinacine (0–12.5 μM) for 4 h. In all, 2 μM of doxorubicin was added, and the cells were allowed to incubate overnight. Cell viability was measured by MTT assay, and the viability of cells untreated with small molecules was set at 100%. Experiments were performed in triplicate, and error bars indicate the S.D.